Neurology · 3 h ago
Sleep-Disordered Breathing Linked to Worse Outcomes After Stroke or TIA
In a retrospective cohort of 1,083 patients with ischemic stroke or transient ischemic attack, sleep-disordered breathing was common and greater severity was associated with adverse outcomes. Severe sleep-disordered breathing was associated with higher long-term mortality, while all severity levels were associated with post-event cardiovascular or cerebrovascular events.
- SDB was detected in 75.6% of the cohort.
- Severe SDB was associated with higher mortality.
- All SDB severity levels were associated with MACCE.
- The observational findings do not establish treatment benefit.
This retrospective cohort study included 1,083 consecutive patients with ischemic stroke or transient ischemic attack admitted to Inselspital Bern from 2017 to 2021 who underwent in-hospital respiratory polygraphy. Sleep-disordered breathing (SDB) was classified by apnea-hypopnea index as mild, moderate, or severe. The investigators assessed all-cause mortality, first postindex major adverse cardio- and cerebrovascular events (MACCE), and 3-month functional outcome, adjusting for demographic, vascular, and stroke-related factors.
SDB was present in 819 patients (75.6%). Over a median mortality follow-up of 51.1 months, severe SDB was associated with higher all-cause mortality (adjusted hazard ratio [HR], 1.73; 95% CI, 1.04–2.89). Mild, moderate, and severe SDB were each associated with first postindex MACCE (adjusted HRs, 1.78, 2.20, and 2.16, respectively). Moderate and severe SDB were also associated with unfavorable 3-month functional outcome (adjusted odds ratios, 1.74 and 2.48).
The findings suggest that SDB severity may help identify patients with poorer prognosis after stroke or TIA. As an observational study from a single center, it establishes associations rather than causation; it does not show that screening or treating SDB improves outcomes.
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Stroke: Sleep-Disordered Breathing Is Associated With Adverse Short- and Long-Term Outcomes in Acute Ischemic Stroke and TIA: A Retrospective Cohort Study From the Bern Sleep-Stroke Registry ↗This is an automated AI-condensed summary that has not yet been reviewed by an editor. Always consult the full item at the original source.