Endocrinology · Pediatrics · 1 h ago
Childhood Amino Acid Profiles Linked to Later Dysglycemia Risk in BCAMS Cohort
A prospective analysis of 947 children in the Beijing BCAMS cohort found distinct amino acid profiles across glycemic phenotypes. Among 297 participants with baseline normoglycemia who completed follow-up testing, childhood insulin resistance and several amino acids were associated with dysglycemia risk over 10 years.
- Childhood insulin resistance was linked to higher later dysglycemia risk.
- Six amino acids were associated with 10-year risk.
- Isoleucine restriction findings came from obese mice.
- Clinical utility of amino acid profiling remains unestablished.
Researchers analyzed targeted plasma metabolomics data from 947 children in the Beijing Children and Adolescents Metabolic Syndrome study. Participants were classified as normoglycemic with insulin sensitivity, normoglycemic with insulin resistance, or having impaired fasting glucose. At 10-year follow-up, 297 participants who had been normoglycemic underwent an oral glucose tolerance test to assess dysglycemia. The analysis also measured five adipokines.
A cluster of amino acids, including isoleucine, valine, tyrosine, phenylalanine, alanine and proline, was independently associated with insulin resistance and impaired fasting glucose. Children with normoglycemia and insulin resistance had a 4.3-fold higher risk of dysglycemia at follow-up than those with normoglycemia and insulin sensitivity. Six amino acids were associated with 10-year risk; adding them to clinical variables improved prediction. The authors also reported metabolic changes after dietary isoleucine restriction in obese mice.
The findings suggest childhood amino acid profiles may help identify metabolic risk before dysglycemia develops, but do not establish a clinical testing strategy or show that amino acid modification prevents diabetes in people. Follow-up outcome testing was available for a subset, and the intervention evidence came from mice.
Is this summary clinically accurate?
Help fellow clinicians: your rating sends inaccurate summaries straight to our editors.
Sign in to rate this summary →Source
Diabetes: Amino Acid Profiles Distinguish Glycemic Phenotypes in Childhood and Predict 10-Year Risk of Dysglycemia in Young Adults: The BCAMS Study ↗This is an automated AI-condensed summary that has not yet been reviewed by an editor. Always consult the full item at the original source.