Obstetrics & Gynecology · Endocrinology · 1 h ago
Scoping review finds limited evidence on women’s health in osteogenesis imperfecta
A scoping review screened more than 1,300 articles published from 1967 to 2026 on menarche, fertility, pregnancy and menopause in women with osteogenesis imperfecta (OI). Evidence suggests pregnancy is often successful but may carry higher risks of complications and fractures; the underlying studies are generally small and limited by OI subtype.
- Menarche appears similar to the general population.
- Pregnancy is often successful, but complications may be more frequent.
- Evidence on menopause and OI remains sparse.
- Small studies and subtype variation limit conclusions.
Osteogenesis imperfecta is a heterogeneous group of connective tissue disorders most often associated with changes in type I collagen. This scoping review examined literature on menarche, pregnancy, menopause and periods of skeletal stress in women with OI. The authors identified and screened more than 1,300 articles published between 1967 and 2026; the supplied text does not report the number ultimately included or describe a pooled analysis.
The reviewed literature suggests age at menarche is similar to that in the general population, and fertility may be preserved, particularly in milder OI phenotypes. Most reported pregnancies were successful, although studies suggest increased risks of complications and fractures compared with the general population. Caesarean delivery was also reported more frequently. Evidence on menopause is sparse, and differences in menopausal symptoms or consequences have not been established.
The authors conclude that evidence to guide monitoring and treatment across women’s health in OI remains limited. Small study sizes and variation in OI subtypes constrain interpretation; the review does not provide quantified risk estimates or a standardized management approach. It emphasizes individualized monitoring during pregnancy and menopause, with attention to known complications.
In practice
For clinicians caring for women with osteogenesis imperfecta, the review indicates that fertility may be preserved and most reported pregnancies are successful, but available studies suggest more pregnancy complications and fractures, and more frequent caesarean delivery, than in the general population. The evidence is not strong enough to define a standardized monitoring or treatment approach: studies are small, vary by OI subtype, and menopause-related outcomes are poorly described. The authors support individualized monitoring focused on known complications, rather than a specific change in practice.
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Osteoporosis International: Women’s health in osteogenesis Imperfecta: a scoping review ↗This is an automated AI-condensed summary that has not yet been reviewed by an editor. Always consult the full item at the original source.