Dermatology · General Practice · 2 h ago
Large UK study maps comorbidities associated with psoriasis
A UK longitudinal cohort study compared 320,220 people with psoriasis with 1,706,424 matched individuals using linked primary- and secondary-care records. Associations were found across 225 disease groups, including liver disease, substance misuse and respiratory conditions; the authors say the findings may generate hypotheses about comorbidity.
- UK cohorts included over 320,000 people with psoriasis.
- Associations spanned 225 disease groups.
- Long-term associations included liver disease and substance misuse.
- Observational findings generate hypotheses, not screening recommendations.
Researchers used UK Clinical Practice Research Datalink Aurum records linked to Hospital Episode Statistics to examine hospital-recorded comorbidities in people with psoriasis. Cohorts were matched for age, sex and general practice. The study assessed associations during the first year after psoriasis diagnosis and in the subsequent period, using Cox regression adjusted for alcohol use, smoking, BMI and social deprivation. In total, 320,220 people with psoriasis were compared with 1,706,424 matched individuals across 225 ICD-10 condition groups.
In long-term analyses, psoriasis was associated with liver disease (hazard ratio [HR] 1.47; 99% CI 1.42–1.51), substance misuse, including alcohol and tobacco (HR 1.26; 99% CI 1.25–1.28), and respiratory diseases, principally affecting the interstitium (HR 1.33; 99% CI 1.27–1.40). Associations were observed across multiple organ systems. The authors describe the results as evidence of associations that may identify underappreciated comorbidities and generate hypotheses. The observational design cannot establish causality, and the findings alone do not determine whether screening practices should change.
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British Journal of Dermatology: Phenome-wide Longitudinal Association Study of Hospital-recorded Comorbidity in Psoriasis ↗This is an automated AI-condensed summary that has not yet been reviewed by an editor. Always consult the full item at the original source.