Rheumatology · Pulmonology · 1 h ago
US study estimates incidence and prevalence of CTD-associated interstitial lung disease
A retrospective analysis of US electronic health record and insurance claims data from 2019 to 2024 estimated CTD-associated interstitial lung disease (CTD-ILD) incidence and prevalence. Across two databases, ILD was identified in 3.2% to 4.3% of patients with connective tissue diseases, with the highest subtype-specific proportion in systemic sclerosis.
- ILD affected 3.2%–4.3% of identified CTD patients.
- Systemic sclerosis had the highest CTD-ILD proportion.
- Adjusted incidence estimates were 7.6–10.0 per 100,000 person-years.
- Rates varied by subtype and demographic group.
Researchers used Optum de-identified electronic health records and MarketScan commercial and Medicare claims data to identify patients with rheumatoid arthritis, systemic sclerosis, systemic lupus erythematosus, idiopathic inflammatory myopathy, mixed connective tissue disease, or Sjögren’s disease from 2019 through 2024. The analysis estimated CTD-ILD incidence and prevalence overall and by underlying disease subtype.
ILD was identified in 21,366 of 496,690 patients with CTD in Optum (4.3%) and 7,521 of 234,468 in MarketScan (3.2%). The proportion was highest among patients with systemic sclerosis: 20.3% and 21.1%, respectively. Age- and sex-adjusted incidence was 7.6 and 10.0 per 100,000 person-years, while adjusted prevalence was 46.7 and 43.4 per 100,000 people. Across both databases, rates were highest for RA-ILD and lowest for MCTD-ILD. Crude rates were higher among women, people aged 65 years or older, and patients of Black African ancestry.
The two databases provide contemporary US estimates, but the findings are based on observational administrative and health record data. The study describes disease frequency and distribution; it does not test screening strategies or establish that these estimates should change clinical practice.
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Clinical Rheumatology: Incidence and prevalence of connective tissue disease (CTD)-associated interstitial lung disease in the United States ↗This is an automated AI-condensed summary that has not yet been reviewed by an editor. Always consult the full item at the original source.