Internal Medicine · 2 h ago
Indian sepsis survivors face substantial long-term mortality and readmission
A multicenter observational follow-up study tracked 608 adults discharged alive after sepsis in Indian ICUs. Over as long as 39 months, 41.9% died and 33.2% were readmitted; greater comorbidity burden was associated with worse outcomes.
- Follow-up included 608 Indian ICU sepsis survivors.
- Mortality reached 41.9% over up to 39 months.
- One-third of patients were readmitted.
- Higher comorbidity burden was associated with poorer outcomes.
The LOSS study followed adults enrolled in the SEPSIS INDIA registry who survived hospital discharge. Researchers used registry data to assess comorbidity burden with the Charlson Comorbidity Index (CCI), then collected mortality, hospital readmission and health-related quality-of-life outcomes through structured telephone interviews. Follow-up extended to 39 months after discharge. The cohort included 608 patients; median age was 65 years, and 58.1% were male.
During follow-up, 251 patients (41.9%) died and 202 (33.2%) were readmitted. Higher CCI at the index admission independently predicted long-term mortality (OR 1.403; 95% CI 1.249–1.577; p<0.0001) and was associated with increased readmission risk. Among survivors with available quality-of-life data, 19.1% reported deterioration in physical quality of life and 16.9% in mental quality of life. Higher CCI independently predicted worse outcomes in both domains.
The findings describe a substantial burden after sepsis discharge and identify comorbidity burden as an important prognostic correlate in this cohort. As an observational study, it cannot establish that comorbidities caused these outcomes or show which follow-up interventions might improve them. Quality-of-life results were available only for a subset of survivors.
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Critical Care: Long-term outcomes of sepsis survivors in Indian sepsis registry: the LOSS study ↗This is an automated AI-condensed summary that has not yet been reviewed by an editor. Always consult the full item at the original source.