Gastroenterology · Public Health · 26 Oct
Sedentary time and poorer cardiovascular health linked to gallstone risk
A prospective UK Biobank cohort study of 307,919 adults found that greater self-reported sedentary time and lower Life’s Essential 8 cardiovascular health scores were associated with incident gallstone disease. Over a median 13.73 years, 10,911 participants developed gallstones; the strongest association was among those with both high sedentary time and low cardiovascular health.
- 10,911 participants developed gallstone disease during follow-up.
- Each additional sedentary hour was associated with 8% higher risk.
- Low cardiovascular health was associated with 2.80-fold higher risk.
- High sedentary time plus low cardiovascular health had the strongest association.
Researchers followed 307,919 UK Biobank participants who had no gallstone disease at baseline to examine associations between sedentary time, cardiovascular health and new gallstone disease. Participants reported time spent watching television, using a computer outside work and driving. Cardiovascular health was assessed using the American Heart Association’s Life’s Essential 8 score. The analysis used multivariable Cox models and a combined categorization of sedentary time and cardiovascular health.
In practice
In this large UK Biobank cohort, greater self-reported sedentary time and lower Life’s Essential 8 scores were associated with higher incidence of gallstone disease, including a higher observed risk among participants with both high sedentary time and low cardiovascular health. These findings may inform discussions of general health behaviors, but they do not show that reducing sedentary time or improving cardiovascular health will prevent gallstones. The measures were self-reported, and residual confounding is possible; the study does not establish a gallstone-specific prevention strategy.
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BMC Public Health: Associations of sedentary time and cardiovascular health with gallstone disease: evidence from a prospective cohort study ↗This is an automated AI-condensed summary that has not yet been reviewed by an editor. Always consult the full item at the original source.