Pediatrics ·
Pediatric ICUs in Türkiye and Northern Cyprus: Platelet Transfusion Practices
A prospective observational study across 22 PICUs recorded 577 platelet transfusions among 200 children from 2,693 admissions. Two-thirds of transfusions were prophylactic, and the median pretransfusion platelet count for isolated thrombocytopenia was higher than the threshold in the 2022 TAXI-CAB consensus recommendations.
- 200 of 2,693 PICU patients received platelet transfusions.
- Prophylaxis accounted for 66.4% of transfusion episodes.
- Median count in isolated thrombocytopenia was 24 × 10⁹/L.
- Transfusion was associated with higher 28-day mortality odds.
This prospective observational study examined platelet transfusion practices in 22 PICUs in Türkiye and Northern Cyprus from October to December 2024. It included children aged 1 month to 18 years who received at least one platelet transfusion. Researchers compared transfusion practices with the 2022 TAXI-CAB recommendations and assessed associations with 28-day mortality.
Among 2,693 PICU admissions, 200 children (7.4%) received 577 transfusions. Prophylaxis accounted for 383 episodes (66.4%); isolated thrombocytopenia was the most frequent prophylactic indication (194/383, 50.7%). In those cases, the median pretransfusion platelet count was 24 × 10⁹/L (IQR 16–38), compared with the TAXI-CAB guidance of less than 10 × 10⁹/L. Receiving a platelet transfusion was associated with 20-fold greater odds of 28-day mortality (p<0.001). Among transfused patients, lower pretransfusion platelet count, invasive mechanical ventilation, and hospital-acquired infections contributed to mortality classification in the multivariable model.
The observational findings describe practice and associations; they do not establish that transfusion caused higher mortality or explain why clinicians used higher thresholds. The authors note the heterogeneity of patients and practice settings and call for further research to inform future recommendations.
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Pediatric Critical Care Medicine: Platelet Transfusion Practices in the PICUs: Multicenter, Observational Study, in Türkiye and Northern Cyprus, 2024 ↗This is an automated AI-condensed summary that has not yet been reviewed by an editor. Always consult the full item at the original source.