Pediatrics · Nephrology · Surgery ·
Preoperative NET Levels Associated With Complications After Pediatric Cardiopulmonary Bypass
In a single-center prospective cohort of 118 children undergoing cardiopulmonary bypass, researchers assessed whether preoperative plasma neutrophil extracellular trap (NET) levels were associated with postoperative outcomes. Higher levels were observed more often in patients who developed acute kidney injury; NET levels were also associated with necrotizing enterocolitis in an unadjusted analysis.
- AKI occurred in 31% of the cohort.
- Higher NET levels were more frequent with postoperative AKI.
- NETs were associated with NEC in unadjusted analysis.
- No association was found with several other outcomes.
This single-center prospective observational study included 118 patients from birth to younger than 18 years who underwent cardiopulmonary bypass between June 2022 and June 2024. Investigators measured preoperative plasma NETs using myeloperoxidase-DNA complexes and assessed postoperative acute kidney injury (AKI) using KDIGO serum creatinine or urine output criteria, with creatinine corrected for fluid balance. Outcomes also included necrotizing enterocolitis (NEC), length of stay, chylothorax, thrombosis, and vasoactive-ventilator-renal score.
AKI occurred in 31% of patients. Higher preoperative NET levels were more frequent among patients with postoperative AKI and among patients with lower Society of Thoracic Surgeons-European Association for Cardio-Thoracic Surgery scores of 1–3. Each 1-SD increase in NET levels was associated with higher odds of NEC in an unadjusted analysis (OR 2.61; 95% CI 1.29–5.31). NET levels were not associated with cardiac ICU or hospital length of stay, chylothorax, thrombosis, or VVR score.
The findings suggest a possible association between preoperative NET levels and selected early complications after pediatric bypass, but do not establish causality or support using NETs to guide care. The cohort was single-center, and the NEC association was unadjusted; validation in further studies is needed.
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Pediatric Critical Care Medicine: Neutrophil Extracellular Traps and Acute Kidney Injury in Pediatric Patients Receiving Cardiopulmonary Bypass ↗This is an automated AI-condensed summary that has not yet been reviewed by an editor. Always consult the full item at the original source.