Endocrinology · 2 h ago
GMI-to-HbA1c ratio associated with microvascular complications in type 1 diabetes
A multicenter cross-sectional study of 1,315 people with type 1 diabetes found that the GMI/HbA1c ratio was associated with microvascular complications after adjustment for clinical and glucose-monitoring measures. Complication prevalence was highest among participants in the high-glycator group, but the study cannot establish causation or show that ratio-based screening improves outcomes.
- Complication prevalence was highest in the high-glycator tertile.
- The ratio remained associated with complications after adjustment.
- Cross-sectional findings do not establish causation or guide screening changes.
This multicenter, cross-sectional observational study included 1,315 people with type 1 diabetes of at least five years’ duration who used continuous glucose monitoring. Participants needed at least 80% CGM coverage during the 56 days before HbA1c measurement. Researchers grouped participants into tertiles according to their GMI/HbA1c ratio and assessed associations with grouped microvascular complications and ocular disease using logistic regression.
Microvascular complications were reported in 38.9% of the high-glycator group, compared with 28.2% of the intermediate and 23.7% of the low-glycator groups. Ocular disease prevalence was 31.0%, 20.2% and 19.7%, respectively; nephropathy and polyneuropathy were also more prevalent in the high-glycator group. The ratio remained associated with grouped complications (OR 0.71, 95% CI 0.61–0.81) and ocular disease (OR 0.71, 95% CI 0.61–0.82) after adjustment.
The findings suggest that the relationship between CGM-derived GMI and laboratory HbA1c may help identify differences in complication burden. However, the cross-sectional design cannot establish temporal or causal relationships, and the study does not demonstrate that using the ratio to alter screening or treatment improves outcomes.
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Diabetes, Obesity and Metabolism: Association Between the GMI / HbA1c Ratio and Microvascular Complications in Type 1 Diabetes: A Multicenter Cross‐Sectional Study ↗This is an automated AI-condensed summary that has not yet been reviewed by an editor. Always consult the full item at the original source.