Neurology ·
Review examines how Parkinson disease genetics could inform precision care
A Nature Reviews Neurology review surveys three decades of genetic research in Parkinson disease and its potential clinical applications. It describes how genetic findings may inform diagnosis, counselling and research into targeted therapies, while noting limitations including incomplete penetrance and ancestry-related gaps.
- Genetic findings span monogenic forms and common risk variants.
- More than 100 loci have been associated with Parkinson disease.
- Genetics may help define biologically distinct disease groups.
- Incomplete penetrance and ancestry gaps remain important limitations.
Parkinson disease has a varied genetic architecture, ranging from rare monogenic forms to common variants with modest effects on susceptibility. This review surveys genetic discoveries over the past three decades and discusses their current and potential roles in clinical care and therapeutic development; it does not report a new patient cohort or trial.
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Nature Reviews Neurology: Translating Parkinson disease genetics into clinical benefit ↗This is an automated AI-condensed summary that has not yet been reviewed by an editor. Always consult the full item at the original source.