Infectious Disease ·
ICOPE-Aligned Screening for Intrinsic Capacity in People With HIV Shows Variable Performance
A study of 202 people with HIV assessed a brief questionnaire-based screen for intrinsic-capacity deficits against in-depth assessments. Performance varied across domains, and the authors say local validation is needed before implementation, particularly for cognition and vitality.
- Screening accuracy varied substantially across intrinsic-capacity domains.
- Cognition and vitality items performed modestly.
- Combined items increased sensitivity but reduced specificity.
- Local validation is needed before routine implementation.
The WHO Integrated Care for Older People (ICOPE) framework uses brief screening of functional domains to identify people who may need in-depth assessment. This study evaluated questionnaire items for screening intrinsic capacity (IC) in 202 people with HIV (median age, 50.5 years; 78.2% male), comparing domain-level screening performance with in-depth IC assessments. Performance was stratified by age, and the researchers examined associations between identified impairment and participant characteristics and outcomes.
Screening performance varied substantially across domains. Individual items for cognition and vitality performed modestly, while mobility, mood and vision performed relatively better. Combining items increased sensitivity but reduced specificity. Using the selected screening items, 85% of participants were classified as having IC impairment; this classification was associated with poorer quality of life and greater social vulnerability.
The findings suggest that brief ICOPE-aligned questions can be used to identify potential IC deficits in HIV care, but the variability in performance limits confidence in a single screening approach. The study supports local validation before routine implementation, especially for cognition and vitality. The source does not provide domain-specific performance estimates, and the reported associations do not establish that screening or subsequent assessment improves health outcomes.
In practice
For people with HIV, this questionnaire-based ICOPE-aligned screen may help flag possible intrinsic-capacity deficits for further assessment, but the study does not establish that screening improves outcomes. Performance differed across domains: cognition and vitality items were modest, while mobility, mood and vision performed relatively better. Combining items increased sensitivity at the cost of specificity. The authors recommend local validation before implementation, particularly for cognition and vitality; these findings alone do not support treating the tool as a validated universal screening standard.
AI-generated clinical interpretation · Not editor-reviewed
Is this summary clinically accurate?
Help fellow clinicians: your rating sends inaccurate summaries straight to our editors.
Sign in to rate this summary →Source
AIDS: Diagnostic performance of the ICOPE-aligned screening tool for intrinsic capacity in people with HIV: considerations for implementation ↗This is an automated AI-condensed summary that has not yet been reviewed by an editor. Always consult the full item at the original source.