Endocrinology · Cardiology · 2 h ago
Higher TSH Linked to Modest Lipid Differences in Indian Older Adults
A weighted observational analysis of 6,168 participants in the Longitudinal Ageing Study in India examined TSH and metabolic cardiovascular markers across two waves. Higher TSH was associated with modestly higher LDL and total cholesterol at the first wave, but the findings were not consistent in later analyses; an exploratory Chinese inpatient comparison was imprecise.
- First-wave TSH associations with LDL and total cholesterol were modest.
- Primary-analysis associations did not meet the FDR threshold.
- Later-wave and inpatient estimates were imprecise.
- The study does not establish causality or cardiovascular-event risk.
Researchers analysed data from 6,168 participants in Harmonized LASI-DAD, with measurements collected in 2017–2019 and 2022–2024. Weighted models assessed associations between log-transformed thyroid-stimulating hormone (TSH) and metabolic cardiovascular markers, adjusting for demographic and other factors. Two-wave models also adjusted for baseline outcome values. An exploratory, retrospective analysis included 251 inpatient records from Jilin University First Hospital in China.
At the first wave, higher log(TSH) was associated with higher LDL cholesterol (β 2.26 mg/dL; 95% CI 0.53–4.00) and total cholesterol (β 2.68 mg/dL; 95% CI 0.71–4.64). These associations did not meet the false-discovery-rate threshold in the primary analysis (FDR p=0.063 for both), although they persisted in a multiple-imputation sensitivity analysis. Wave 2 and two-wave estimates were imprecise and included the null. Estimates from the Chinese inpatient comparison were also imprecise.
The results provide modest cross-sectional evidence of TSH–lipid associations in this Indian analytic sample. They do not establish causality, cardiovascular-event risk, longitudinal persistence, or external validation. The Chinese comparison was exploratory and based on a small inpatient sample.
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BMC Public Health: Thyroid-Stimulating hormone and metabolic cardiovascular risk markers from weighted two-wave analyses of india with an exploratory Chinese inpatient comparison ↗This is an automated AI-condensed summary that has not yet been reviewed by an editor. Always consult the full item at the original source.