Neurology · Cardiology · 3 h ago
US study describes post-ICH prevention strategies in patients with atrial fibrillation
A multicenter observational study using linked data from 29 US healthcare organizations identified 2,276 adults with atrial fibrillation hospitalized for intracerebral hemorrhage from 2016 to 2024. By five years after discharge, an estimated 59.8% had received anticoagulation and 4.5% had undergone left atrial appendage closure.
- Cohort included 2,276 patients with AF and ICH.
- Five-year anticoagulation rate was 59.8%.
- LAA closure rate was 4.5% at five years.
- Study describes practice patterns, not treatment outcomes.
Researchers used linked electronic health record, pharmacy, and insurance claims data in the TriNetX Linked platform to examine US treatment patterns after intracerebral hemorrhage (ICH) in adults with atrial fibrillation (AF). The cohort included 2,276 patients hospitalized from 2016 through 2024. Mean age was 65.4 years, 40.6% were female, and the median CHA₂DS₂-VASc score was 5. About 27% had received an anticoagulant prescription in the 90 days before ICH.
Estimated cumulative five-year treatment rates were 59.8% for anticoagulation (95% CI, 55.5%–64.2%), 39.9% for antiplatelet therapy (95% CI, 34.1%–46.3%), and 4.5% for left atrial appendage (LAA) closure (95% CI, 2.6%–7.6%). LAA closure rates did not differ by the date of the index ICH (P=0.88). The findings describe varied secondary stroke-prevention approaches in this population, where the balance between ischemic and hemorrhagic risk remains uncertain. As an observational analysis of coded records and prescriptions, the study reports utilization patterns, not comparative treatment safety or effectiveness.
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Stroke: Contemporary US Practice Patterns Regarding Anticoagulation and LAA Closure in ICH Survivors With Atrial Fibrillation ↗This is an automated AI-condensed summary that has not yet been reviewed by an editor. Always consult the full item at the original source.