Cardiology · 5 h ago
Risk-weighted apoB was associated with coronary events across ethnic groups
A pooled analysis of 40,132 participants from five cohort studies examined risk-weighted apolipoprotein B (RW-apoB) and coronary events across ethnic groups. RW-apoB was associated with events beyond measured apoB, but improvements in discrimination were statistically significant only in the White and Chinese groups.
- RW-apoB was associated with events beyond measured apoB.
- Discrimination gains were significant in White and Chinese groups.
- No significant discrimination gain was shown in the other groups.
Apolipoprotein B (apoB) estimates the number of circulating atherogenic lipoproteins, while risk-weighted apoB (RW-apoB) also incorporates triglyceride-rich lipoproteins and lipoprotein(a). Researchers analyzed 40,132 participants in ARIC, CARDIA, MESA, the Framingham Offspring Study and China Kadoorie Biobank; 4,509 coronary events occurred. They calculated RW-apoB using a prespecified equation and compared its association with events and its predictive discrimination against measured apoB across ethnic groups.
After adjustment for apoB, each 10 mg/dL higher RW-apoB was associated with coronary events among White participants (hazard ratio [HR] 1.11, 95% CI 1.05–1.18), African American participants (HR 1.11, 1.08–1.15), Chinese participants (HR 1.08, 1.05–1.11) and Hispanic participants (HR 1.10, 1.01–1.21). C-indices were higher for RW-apoB than apoB in White participants (0.630 vs 0.617; P<0.001) and Chinese participants (0.567 vs 0.554; P=0.014). Differences were not statistically significant in African American or Hispanic participants.
The findings suggest that weighting apoB for other lipoprotein characteristics captures risk information beyond apoB alone, but improvements in discrimination varied by group. The abstract does not establish whether using RW-apoB changes clinical decisions or outcomes; full-text details were unavailable.
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European Journal of Preventive Cardiology: Risk-weighted apoB and lipoprotein-associated coronary risk across ethnic groups ↗This is an automated AI-condensed summary that has not yet been reviewed by an editor. Always consult the full item at the original source.