Endocrinology · 2 h ago
Review examines metabolic differences in obesity
This review discusses why people with obesity differ in insulin sensitivity and related metabolic complications. It compares metabolically healthy and unhealthy obesity across cellular, organ-system and systemic levels, and considers variation in responses to weight reduction.
- Insulin sensitivity varies among people with obesity.
- The review compares metabolically healthy and unhealthy obesity.
- Weight reduction may have heterogeneous metabolic effects.
Insulin resistance across multiple organ systems is described as a key driver of obesity-related complications, including atherogenic dyslipidemia, metabolic dysfunction-associated steatotic liver disease and type 2 diabetes. Yet insulin sensitivity varies among people with obesity. The review contrasts metabolically healthy obesity—characterized by normal insulin sensitivity and specified normal glucose, lipid and liver-fat measures—with metabolically unhealthy obesity. It discusses differences at cellular, organ-system and systemic levels, as well as heterogeneity in the metabolic effects of weight reduction. The authors argue that understanding these differences and responses to weight loss may help clarify how excess adiposity is linked to metabolic dysfunction and disease.
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Nature Medicine: Metabolic heterogeneity of obesity ↗This is an automated AI-condensed summary that has not yet been reviewed by an editor. Always consult the full item at the original source.