Gastroenterology · Hematology ·
Gastric MALT lymphoma risk normalizes six years after H. pylori treatment
A population-based cohort study in four Nordic countries followed 567,984 people after Helicobacter pylori eradication treatment. Gastric MALT lymphoma incidence was elevated during years 1–5 but was not higher than in the background population during years 6–18.
- Cohort included 567,984 people treated for H. pylori.
- Twenty-three gastric MALT lymphomas occurred during follow-up.
- Incidence was elevated in years 1–5 after treatment.
- Incidence in years 6–18 was not higher than background.
Researchers conducted a population-based cohort study of people who received Helicobacter pylori eradication treatment in Finland, Iceland, Norway, or Sweden between 1999 and 2023. Using nationwide health and cancer registries, they compared gastric MALT lymphoma incidence with that of people matched by age, sex, calendar period, and country in the background population. Follow-up extended to 18 years.
Among 567,984 treated individuals, representing 4,811,322 person-years, 23 gastric MALT lymphomas were identified. Incidence was higher than in the background population during the first 1–5 years after treatment (standardized incidence ratio [SIR] 2.65, 95% CI 1.52–4.31). During years 6–18, it was not distinguishable from background incidence (SIR 0.96, 95% CI 0.39–1.99). The pattern was consistent across subgroups defined by sex, age, calendar year, and autoimmune disease.
The findings describe the timing of lymphoma diagnoses after eradication but do not establish why the early incidence was elevated. Only 23 cases occurred, reflected in the wide confidence interval for the later follow-up period. The study does not report evidence that would determine a specific surveillance strategy.
Is this summary clinically accurate?
Help fellow clinicians: your rating sends inaccurate summaries straight to our editors.
Sign in to rate this summary →Source
JNCI: Journal of the National Cancer Institute: The risk of gastric mucosa-associated lymphoid tissue (MALT) lymphoma after Helicobacter pylori eradication treatment ↗This is an automated AI-condensed summary that has not yet been reviewed by an editor. Always consult the full item at the original source.