Oncology ·
Liver Metastases Reprogram Hematopoiesis to Suppress Antitumor Immunity
A mechanistic study reported in Science describes how liver metastases establish local blood-cell-producing niches that favor immunosuppressive myeloid cells. The findings suggest a pathway linking hepatic hematopoiesis to impaired CD8+ T-cell and natural killer cell function.
- Liver metastases were linked to ectopic periportal hematopoietic niches.
- CREB activation favored myeloid differentiation, including immature neutrophils.
- Neutrophil-derived glucocorticoids impaired CD8+ T and natural killer cells.
The study examined how tumors may drive localized hematopoiesis in the liver and affect antitumor immunity. The authors describe periportal hematopoietic niches associated with liver metastases that recruit bone marrow hematopoietic stem cells through Kupffer cell–dependent CCR1 signaling. The abstract does not provide species, sample size, or experimental methods.
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Science: Tumor metastasis co-opts liver hematopoiesis to promote immunosuppression ↗This is an automated AI-condensed summary that has not yet been reviewed by an editor. Always consult the full item at the original source.