Pulmonology · 2 h ago
Primary Graft Dysfunction Linked to Lower Lung Function After Transplant
In an eight-center prospective cohort of 2,419 lung transplant recipients, primary graft dysfunction (PGD) was associated with lower maximum potential FEV1. PGD was not associated with a higher five-year cumulative incidence of chronic lung allograft dysfunction (CLAD).
- PGD was associated with 311-mL lower maximum potential FEV1.
- Recipients with PGD were less likely to attain predicted FEV1.
- Five-year CLAD incidence did not differ by PGD status.
Researchers analyzed lung transplant recipients enrolled in an eight-center prospective cohort from 2007 to 2018. Among 2,419 recipients, 510 had PGD, defined using International Society for Heart and Lung Transplantation criteria. Models assessed maximum potential FEV1, attainment of predicted FEV1, and CLAD, accounting for confounding and treating mortality as a competing risk.
Recipients with PGD had a 311-mL lower maximum potential FEV1 (95% CI, 245 to 377 mL lower) and were 12.5 percentage points less likely to attain GLI-predicted FEV1 (95% CI, 8 to 17 points lower). Over a median 5.9 years, 930 recipients developed CLAD. Five-year cumulative incidence did not differ significantly by PGD status; findings were similar for obstructive and restrictive CLAD.
The observational results associate PGD with reduced long-term lung function, but not with increased CLAD incidence. The findings do not establish that PGD causes the lung-function differences or indicate a change in clinical management.
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American Journal of Respiratory and Critical Care Medicine: Lung Allograft Function After Primary Graft Dysfunction in the Lung Transplant Outcomes Group Cohort ↗This is an automated AI-condensed summary that has not yet been reviewed by an editor. Always consult the full item at the original source.