Nephrology · 16 h ago
ADPKD Linked to Higher VTE Risk After Kidney Transplantation
In two observational cohorts totaling 5,594 adult kidney transplant recipients, those with ADPKD had higher post-transplant venous thromboembolism incidence than recipients without ADPKD. The association persisted after adjustment and was partly attenuated when hemoglobin levels were included in the analysis.
- ADPKD was associated with higher post-transplant VTE risk.
- Ten-year VTE incidence was higher in both cohorts.
- The association was partly attenuated after accounting for hemoglobin.
- VTE risk was highest within two years after transplantation.
Researchers studied adult kidney transplant recipients at the University Medical Center Groningen (UMCG; 1,179 recipients, including 393 with ADPKD) and replicated key analyses in the Swiss Transplant Cohort Study (4,415 recipients, including 710 with ADPKD). The primary outcome was time to first post-transplant venous thromboembolism (VTE) or VTE-related death, identified by medical record review.
Ten-year cumulative VTE incidence was 13.5% in recipients with ADPKD versus 9.6% in those without it at UMCG, and 21.0% versus 15.1% in the Swiss cohort. Risk was highest during the first two years after transplantation. After adjustment for VTE risk factors, ADPKD remained associated with VTE in both cohorts: hazard ratio 1.80 (95% CI 1.21–2.69) at UMCG and 1.39 (1.13–1.72) in the Swiss cohort. The association was more pronounced in men.
Recipients with ADPKD had higher post-transplant hemoglobin levels and more erythrocytosis. Accounting for longitudinal hemoglobin attenuated the ADPKD–VTE association, suggesting it may partly explain the increased risk. The observational findings establish an association, not causation, and do not assess whether altered thromboprophylaxis improves outcomes.
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Journal of the American Society of Nephrology: Risk of Venous Thromboembolism in Kidney Transplant Recipients with Autosomal Dominant Polycystic Kidney Disease ↗This is an automated AI-condensed summary that has not yet been reviewed by an editor. Always consult the full item at the original source.