Review maps kidney signaling with other organs in health and disease

The review describes the kidney as an active participant in systemic homeostasis, both receiving and sending signals to distant tissues. The authors summarize proposed molecular mediators and causal models of kidney–organ communication, including circulating factors, neuroimmune circuits, microbial pathways and tissue-specific signaling. No new patient cohort or clinical trial is reported; the article synthesizes mechanistic research rather than presenting a defined clinical intervention or sample size.

The authors identify limitations in current research, including reliance on global genetic manipulation, indirect measurement of signal transfer and study of isolated organ pairs. They suggest that emerging technologies could help identify the cellular origins, routes and consequences of interorgan signals more precisely. The review frames improved understanding as a potential route to biomarkers and therapies with fewer effects on other organs, but reports no validated biomarker, treatment or practice-changing clinical evidence. The supplied record lists a publish-ahead-of-print date of October 28, 2026, which should be verified.