Oncology · 2 h ago
Patient-reported breast satisfaction after pegulicianine-guided lumpectomy
A patient-reported outcomes analysis from two randomized trials found no statistically significant difference in breast satisfaction between patients who did and did not undergo pegulicianine-guided additional margin excision. Most respondents preferred avoiding a second operation over prioritizing cosmetic outcomes, although survey response rates varied substantially between trials.
- Satisfaction scores did not differ significantly by pFGS or additional excision.
- Most respondents preferred avoiding a second surgery.
- Survey completion differed substantially between the two trials.
This analysis examined patient-reported outcomes among patients with stage 0–3 breast cancer enrolled in two randomized trials comparing pegulicianine fluorescence-guided surgery (pFGS) with standard lumpectomy. In the pFGS arm, surgeons could remove additional cavity-margin tissue from sites showing fluorescence. BREAST-Q surveys were completed 6–12 months after surgery; trial 2 also assessed cancer worry and patient preferences.
Mean breast satisfaction scores were 75.8 among patients in the pFGS arm (n=99) and 79.0 among controls (n=19; p=0.53). Scores were 73.6 for patients who had additional pFGS-guided tissue removed (n=52) and 78.5 for those without additional tissue removal (n=66; p=0.17). Among preference respondents, 70.6% preferred or strongly preferred avoiding a second surgery, while 9.8% preferred optimizing cosmetic outcomes; none strongly preferred the latter.
The findings did not show a statistically significant reduction in reported breast satisfaction associated with additional excision. Interpretation is limited by low and uneven survey completion: 14% in trial 1 and 67% in trial 2. The results describe respondents’ reported preferences and do not establish that pFGS improves clinical outcomes or should change surgical practice.
In practice
For patients with stage 0–3 breast cancer undergoing lumpectomy, this analysis found no statistically significant difference in reported breast satisfaction associated with pFGS or additional fluorescence-guided tissue removal. Most preference respondents favored avoiding a second operation over optimizing cosmesis, which may help frame discussions about patients’ priorities. However, survey completion was low in one trial and differed between trials, and these patient-reported findings alone do not establish that pFGS improves outcomes or warrant a change in surgical practice.
AI-generated clinical interpretation · Not editor-reviewed
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Annals of Surgical Oncology: Does Additional Margin Excision During Pegulicianine Fluorescence-Guided Surgery (pFGS) Affect Patient Breast Satisfaction? ↗This is an automated AI-condensed summary that has not yet been reviewed by an editor. Always consult the full item at the original source.