Nephrology · Surgery ·
Long-term outcomes reported for 100 dual kidney transplants from deceased donors
A single-center retrospective review assessed 100 dual kidney transplants (DKTs) performed over 24 years, including outcomes at 10 years or longer for most recipients. Compared with concurrent single transplants from high-KDPI donors, DKT recipients had better patient and graft survival, although death-censored graft survival did not differ.
- Single-center review included 100 dual kidney transplants.
- Most recipients had at least 10 years of follow-up.
- Death-censored graft survival did not differ from comparator.
- DKT activity declined after changes in kidney allocation.
This single-center retrospective study reviewed 100 dual kidney transplants performed over 24 years using kidneys from adult deceased donors. Donors had a mean Kidney Donor Profile Index of 85%, and recipients were selected for low immunological risk and limited nephron requirements. All received antibody induction and tacrolimus, mycophenolate, and steroids. The comparison group comprised 428 concurrent single kidney transplants from high-KDPI donors.
Delayed graft function occurred in 28% of DKT recipients, including two cases of primary nonfunction. At 12 months, mean serum creatinine was 1.49 mg/dL and mean estimated GFR was 55 mL/min/1.73 m². Seventy-nine recipients had at least 10 years of follow-up. Patient and graft survival and renal function were reported as superior to the comparison group; death-censored graft survival was not different. Projected kidney half-lives were 7.8 years for DKT and 5.9 years for high-KDPI single transplants.
The findings suggest DKT can provide acceptable long-term outcomes for selected recipients and kidneys that might otherwise be discarded. The retrospective, single-center design limits generalizability, and the study reports that DKT activity declined after allocation changes; it does not establish the effect of a specific allocation policy.
In practice
For transplant teams considering kidneys with limited functional capacity, this retrospective single-center series suggests that dual transplantation in selected recipients—particularly those with lower nephron requirements—can achieve acceptable long-term outcomes. Outcomes were favorable relative to concurrent single transplants from high-KDPI donors on several measures, but death-censored graft survival was not different. The evidence is observational, reflects one center's selection practices across 24 years, and does not establish that allocation changes caused the observed decline in DKT activity or justify changing allocation practice.
AI-generated clinical interpretation · Not editor-reviewed
Is this summary clinically accurate?
Help fellow clinicians: your rating sends inaccurate summaries straight to our editors.
Sign in to rate this summary →Source
Clinical Transplantation: Long‐Term Outcomes With 100 Dual Kidney Transplants From Adult Deceased Donors: Negative Effect of Changes in Kidney Allocation ↗This is an automated AI-condensed summary that has not yet been reviewed by an editor. Always consult the full item at the original source.